fender GibsonThe question was: which of these two guitars is best for blues?
There is no firm answer, because both are. It depends more on the player's taste or the intent they want to develop. Throughout history we've heard a multitude of blues pieces played on both guitars. Personally, I'd highlight the sharpness of the Fender Stratocaster (although its sound varies quite a bit depending on the pickups).

This instrument has a very special, characteristic attack that, in my view, fits perfectly with many of the intentions that can expand the nuances in a blues solo. As for the Les Paul, I find a powerful appeal in its low end, its round sound, and its strength with gain. In the brief demos here, both qualities have been exaggerated: the cleanness and treble brightness of the Stratocaster, played with string snaps against the fretboard, and, second, a distortion that extends the natural, round, heavy sustain of the Gibson Les Paul on its warmest pickup. This second demo was played with long notes, in order to highlight one (out of hundreds) of the ways of playing blues.

Obviously the sounds could be reversed, taking the Stratocaster to its warmest sound and adding distortion. Conversely, you could make the Les Paul sound on its brightest pickup position and much cleaner. This means that with both we can run through an endless variety of playing styles, although these two demos can give an idea to beginners who want to start clearly telling one guitar from another. The fact that these sounds (as heard in the demos) tend to be characteristic of both guitars (among many other possibilities) is because they are signature settings of the best-known guitarists, who inevitably gravitate toward the cleanness and spark of the Stratocaster, as well as the thick solidity of the Les Paul.